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Image Search Results
Journal: Frontiers in Physiology
Article Title: Aerobic exercise ameliorates atherosclerosis-induced cognitive impairment via hippocampal IL-33/NF-κB signaling modulation
doi: 10.3389/fphys.2025.1608268
Figure Lengend Snippet: Aerobic exercise suppresses the activation of microglia and the expression of inflammatory factors in the hippocampal CA1, CA3, and DG regions of AS mice. (A) Quantitative analysis of inflammatory factors IL-6, TNF-α, and IL-1β in hippocampal tissues from the three groups of mice (n = 4 per group). (B) Coronal sections of the mice hippocampus, delineating the CA1 (cornu amoni 1), CA2, CA3, and DG (dentate gyrus) subfields. (C) Representative immunofluorescence images of Iba1 + (red) and CD68 + (green) microglia in the hippocampal CA1, CA2, CA3, and DG regions across three groups of mice. (D) Quantification of the percentage of Iba1 + and CD68 + microglia relative to the total Iba1 + microglial population in different hippocampal subfields of the three groups of mice (n = 4 per group). Data are shown as Mean ± SEM, * P < 0.05, ** P < 0.01, *** P < 0.001, ns indicating P > 0.05.
Article Snippet: The primary antibodies utilized included anti-Iba1 antibody (1:500, GB12105, Servicebio, China),
Techniques: Activation Assay, Expressing, Immunofluorescence